Withaferin-A Prevents the Onset of Acute Graft versus Host Disease by Inhibiting JAK2-STAT3 Signaling Pathway.

Withaferin-A (WA) as an anti-inflammatory and immunomodulatory agent may have clinical utility either as a single agent or in combination for the prevention of aGvHD. Correspondence to: vgota76@gmail.com I Background: i Acute graft versus host disease (aGvHD) is a major complication of allogenic bone marrow transplantation (alloBMT). [Extracted from the article]