高流量鼻导管氧疗在高海拔性低氧血症中的应用.

Objective　To explore the efficacy of high-flow nasal cannula oxygen therapy on oxygenation in populations at altitudes above 2 500 meters. Methods　Participants were recruited from medium-altitude Kunming （about 1891 m above sea level） to quickly enter higher altitude Lhasa （about 3650 m above sea level）. Participants inhaled air using high-flow nasal cannula oxygen therapy in Lhasa. The pulse oxygen saturation （SpO2），respiratory rate， heart rate and blood pressure were compared before and after the use of high-flow nasal cannula oxygen therapy . Results　In high altitude area，the high flow nasal canula oxygen therapy went well and smoothly. After high-flow nasal catheter oxygen therapy，SpO2 improved and respiratory rate decreased with the increase of inhaled gas flow，the difference was statistically significant （P < 0.05）. After using high-flow nasal cannula oxygen therapy equipment for air inhalation，SpO2 improved and respiratory rate decreased with the increase of inhaled gas flow， the difference was statistically significant （P < 0.05） . Conclusion　High-flow nasal cannula oxygen therapy not only improved participants’ oxygenation，it decreased the effort of breathing，and has potential clinical value in the treatment of high-altitude hypoxemia . [ABSTRACT FROM AUTHOR]