益胃消瘀颗粒对慢性萎缩性胃炎血清胃功能的影响.

Objective To evaluate the effect of Yiwei Xiaoyu Ganules(YWXY) on serum gastric function in chronic atrophic gastritis(CAG). Methods By designing the double-blind, randomized, positive medicine- controlled trial, the effect of YWXY on serum gastric function was evaluated, including pepsinogen-Ⅰ(PG Ⅰ), PGⅡ, PGⅠ/PGⅡ ratio (PGR) and gastrin-17 (G-17). Seventy-two patients with Helicobacter pylori (Hp) negative CAG were recruited and randomly entered the experiment group or control group by a ratio of 1∶1. The experiment group obtained YWXY and Weifuchun simulation preparation(WFC). The control group obtained Weifuchun and YWXY simulation preparation. The treatment course lasted for 24 weeks. Serum gastric function related indexes before and after treatment were detected by the enzyme linked immunosorbent assay (ELISA). Results After 24-week treatment, the level of PGⅠ and PGR in the experiment group were significantly increased compared with before treatment (P <0. 05), while the G-17 level in the control group was decreased compared with before treatment (P <0. 05). The comparison between the two groups after treatment found that the PGⅠ and PGR levels in the experiment group were significantly higher those in the control group (P <0. 05), while PGⅡ had no significant difference(P >0. 05). The serum G-17 expression level in the experiment group was significantly higher than that in the control group. Conclusion YWXY can significantly improve the serum gastric function level in the patients with CAG. [ABSTRACT FROM AUTHOR]