雌激素在正畸过程中对牙移动骨改建及牙根吸收的影响.

BACKGROUND: Orthodontic tooth movement and orthodontic induced root resorption are an important part of orthodontic treatment. Estrogen can regulate the rate of orthodontic tooth movement by influencing the bone remodeling of periodontal tissue, thereby inhibiting orthodontic-induced root resorption. OBJECTIVE: To review the mechanism of estrogen underlying orthodontic tooth movement and orthodontic induction of root resorption. METHODS: The first author searched PubMed, CNKI, and WanFang databases using the keywords of "estrogen; orthodontic tooth movement; orthodontically induced root resorption; osteoclast; osteoblast; bone marrow mesenchymal stem cells; periodontal ligament stem cells" in English and Chinese, respectively. Finally, 53 articles were included for further review. RESULTS AND CONCLUSION: Orthodontic tooth movement is an important part of orthodontic treatment. It can be achieved through bone reconstruction under mechanical force, and alveolar bone reconstruction is the basis of orthodontic tooth movement. Estrogen acts as an important regulator of bone tissue remodeling. Estrogen inhibits osteoclast differentiation, prolongs the life span of osteoclasts, promotes the proliferation, differentiation and function of osteoblasts through a variety of pathways and multiple cytokines, thereby inhibiting bone resorption, promoting bone formation, reducing bone remodeling, and inhibiting orthodontic tooth movement. Estrogen may reduce orthodontics-induced dental root resorption by inhibiting cementoclasts. The differentiation of osteoclasts and odontoclasts is of great significance in the process of tooth movement and root resorption. Recent studies have found that tyrosine kinase acts as an important signal medium for estrogen to inhibit the differentiation, survival and function of human osteoclasts. Although preliminary studies on the role of estrogen in bone remodeling and tooth root resorption have been reported, which mechanism exerts the dominant role has not been elucidated, and most of them are at the stage of basic or animal research. Research on relevant mechanisms and clinical research on this aspect are still needed. [ABSTRACT FROM AUTHOR]