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Chagas disease / COVID-19 comorbidity. An advantage to chagasic patients?
- Source :
-
Revista Biomedica . Sep-Dec2022, Vol. 33 Issue 3, p105-113. 9p. - Publication Year :
- 2022
-
Abstract
- Introduction. Chagas's disease a neglected and debilitating tropical illness, caused by Trypanosoma cruzi-infection, afflicts millions of people in most Latin-American countries. In the same region, frequent and severe viral infection cases have been reported due to SARS-CoV-2, the causative agent of COVID-19, deemed as the worst global pandemic in the 21st century. Objective. To investigate the Chagas disease- COVID-19-relationship, and the comorbidity effect on chagasic patients living in communities where SARS-CoV-2 have circulated during the last two years causing severe cases and deaths. Material and methods. Randomly selected chagasic patients (N=50) from rural localities of western Venezuela, where COVID-19 has occurred, were evaluated in order to know whether they had suffered SARS-CoV-2- infection. COVID-infected chagasic patients were clinically compared with non-chagasic individuals (N=22) who had suffered the viruses in the same localities. Results. SARS-CoV-2-infection caused significantly less aggressive effects in chagasic patients than in nonchagasic patients, evidenced by the short-lasting scarce mild symptoms and the attenuated clinical profile (p<0.05), without further complications. Comparison revealed COVID-19 detection in 10% of chagasic patients, showing all of them mild clinical pattern and few symptoms, while non-chagasic COVID-infected control individuals, showed 45% and 13% severe and fatal cases, respectively. Conclusion. Chagasic patients suffering from COVID-19 comorbidity seem to express a robust immune response (Th1/Th2/Th17), which associated with anti-T. cruzi-glycoproteins circulating antibodies, directed to certain SARS-CoV-2 glycoproteins (membrane/spike), may induce a short lasting and milder clinical profile. More investigations in populations where Chagas disease is endemic, is recommended. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHAGAS' disease
*CORONAVIRUS diseases
*COMORBIDITY
*PANDEMICS
*DISEASE research
Subjects
Details
- Language :
- English
- ISSN :
- 0188493X
- Volume :
- 33
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Revista Biomedica
- Publication Type :
- Academic Journal
- Accession number :
- 161241569
- Full Text :
- https://doi.org/10.32776/revbiomed.v33i3.1054