Inherited and Acquired Vulnerability to Ventricular Arrhythmias: Cardiac Na+ and K+ Channels.

Examines how mutations in cardiac sodium and potassium channel may disrupt the precise balance of ionic currents that underlies normal cardiac excitation and relaxation. Emergence of arrhythmogenic phenotypes leading to syncope, seizures and sudden cardiac death; Congenital defects; Mutation-induced arrhythmia; Development of therapeutic approaches.