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The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review.

Authors :
Suliphuldevara Mathada, Basavarajaiah
Gunavanthrao Yernale, Nagesh
Basha, Jeelan N.
Source :
ChemistrySelect. 1/9/2023, Vol. 8 Issue 1, p1-13. 13p.
Publication Year :
2023

Abstract

Heterocycles are a privileged motif that appears as a momentous objective in medicinal chemistry. An important class of compounds for drug discovery and design is indole and its derivatives, which have been examined for a variety of biological activities. Therefore, it is noteworthy in the modern progress of synthetic, medicinal chemistry; the last decade has been onlooker with a multitude of reports on several indole derivatives corroborating these chemical entities to be a renowned target for the discovery of new drugs. The current study includes brief natural sources of indole, and a new range of commercially available indole‐based drugs. Additionally, this review discusses the numerous facets of the structure‐activity relationship study (SARs) and provides information about the varied pharmacological effects of indole derivatives. The literature data presented for the anti‐pharmacological agents herein covers largely from the year 2015 to mid of 2022. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23656549
Volume :
8
Issue :
1
Database :
Academic Search Index
Journal :
ChemistrySelect
Publication Type :
Academic Journal
Accession number :
161213894
Full Text :
https://doi.org/10.1002/slct.202204181