Back to Search
Start Over
Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
- Source :
-
Journal of Affective Disorders . Feb2023, Vol. 323, p264-279. 16p. - Publication Year :
- 2023
-
Abstract
- <bold>Background: </bold>New research supports an integrated approach to treating depression, and lifestyle modifications should be a regular component of both preventative and treatment programs. Therefore, in order to investigate the relationship between various antioxidant supplements and depressive status, we carried out a meta-analysis of randomized controlled trials (RCT).<bold>Methods: </bold>We thoroughly searched PubMed, Medline, Scopus, and Web of Science databases to screen publications focusing on the effects of antioxidant supplements on depression status. The meta-analysis mainly compared depression scores between groups that received antioxidant supplements and controls. We also pooled studies reporting changes in anxiety status as a secondary outcome.<bold>Results: </bold>52 studies with 4049 participants were eventually identified. The meta-analysis found that the positive effect of antioxidant supplementation, such as magnesium (SMD = 0.16, p = 0.03), zinc (SMD = 0.59, p = 0.01), selenium (SMD = 0.33, p = 0.009), CoQ10 (SMD = 0.97, p = 0.05), tea and coffee (SMD = 1.15, p = 0.001) and crocin (MD = 6.04, p < 0.00001), on depressive status were all significant. And antioxidant supplementation also showed significant improvement in anxiety (SMD = 0.40, p < 0.00001). Subgroup analysis by scale types and countries were performed, and antioxidant supplementation's positive effects on depressive and anxiety states remained significant.<bold>Limitations: </bold>This study did not limit the characteristics of the included population, and the diversity of scales also contributed to the heterogeneity.<bold>Conclusion: </bold>Intake of antioxidant supplements is associated with improved depression and anxiety states, further affirms the therapeutic potential of antioxidant supplements as adjunctive therapy to conventional antidepressants. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CLINICAL trials
*ANXIETY
*MENTAL depression
*DIETARY supplements
*SCIENCE databases
Subjects
Details
- Language :
- English
- ISSN :
- 01650327
- Volume :
- 323
- Database :
- Academic Search Index
- Journal :
- Journal of Affective Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 161172720
- Full Text :
- https://doi.org/10.1016/j.jad.2022.11.072