参松养心胶囊对气阴两虚型糖尿病心血管自主 神经病变患者血液流变学和心血管功能的影响.

OBJECTIVE: To probe into the effects of Shensong Yangxin capsules on hemorheology and cardiovascular function in patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency. METHODS: A total of 130 patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency admitted into Hai’ an Hospital Affiliated to Nantong University from Jul. 2018 to Mar. 2020 were selected to be divided into control group and observation group by random number table method, with 65 cases in each group. The control group was given basic and nutritional treatment of diabetes, while the observation group was treated with Shensong Yangxin capsules. The clinical efficacy, changes of indicators of hemorheology, cardiovascular function and symptom scores, incidences of adverse cardiovascular events and adverse drug reactions of two groups were observed. RESULTS: After 12 weeks of treatment, the fibrinogen and D-dimer levels, the autonomic symptoms scale and composite autonomic symptoms score-31 in the observation group were significantly lower than those before treatment and in the control group, the QT dispersion and Valsalva action index in the observation group were significantly higher than those before treatment and in the control group, with statistically significant differences (P<0. 05). After 12 weeks of treatment, the total effective rate of the observation group was 95. 38% (62/ 65), which was higher than that of control group (83. 08%, 54/ 65), with statistically significant difference (P < 0. 05). After 6 months of follow-up, the incidences of cardiovascular adverse events of the observation group was 6. 15% (4/ 65), lower than 12. 31% (8/ 65) of the control group, with statistically significant difference ( P < 0. 05). CONCLUSIONS: The application of Shensong Yangxin capsules on patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency can improve patients’ hemorheology, promote cardiovascular function, relieve clinical symptoms, improve prognosis, with higher medication safety. [ABSTRACT FROM AUTHOR]