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Ring-closing metathesis in flavonoid synthesis, part 2: neoflav-3-enes.
- Source :
-
ARKIVOC: Online Journal of Organic Chemistry . 2022, Vol. 2022, p217-231. 15p. - Publication Year :
- 2022
-
Abstract
- A series of neoflav-3-enes with a variety of natural substitution patterns was prepared from 1-(allyloxy)-2-[1-(aryl)vinyl]benzenes by Grubbs second generation (GII) catalyst-promoted ring-closing metathesis (67 - 99% yield). The 1-(allyloxy)-2-[1-(phenyl)vinyl]benzene substrates were accessible in yields of 52 - 94% from the corresponding 2-(allyloxy)acetophenones via a Grignard reaction and Lewis acid-promoted dehydration, either in a one pot process in the presence of Al(OTf)3 or in consecutive steps with CuSO4 as dehydrating agent. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15517004
- Volume :
- 2022
- Database :
- Academic Search Index
- Journal :
- ARKIVOC: Online Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 161149214
- Full Text :
- https://doi.org/10.24820/ark.5550190.p011.759