Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023).

B Mechanism of Superenhancer-Driven LncRNA Accelerating Lipid Metabolism b In article number 2204711, Li Peng and co-workers reveal the mechanism of superenhancer-related lncRNA functioning in lipid metabolism. FASRL binding to ACACA, a fatty acid synthesis rate-limiting enzyme, increases lipid accumulation to exacerbate HCC. Upregulation of Superenhancer-Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023). [Extracted from the article]