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Aerobic Training and Circulating Neurotrophins in Alzheimer's Disease Patients: A Controlled Trial.
- Source :
-
Experimental Aging Research . Jan/Feb2023, Vol. 49 Issue 1, p1-17. 17p. 1 Diagram, 4 Charts, 1 Graph. - Publication Year :
- 2023
-
Abstract
- to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer's Disease (AD) patients. 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18 – Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NERVE growth factor
*BIOMARKERS
*SOMATOMEDIN
*EXECUTIVE function
*STATISTICS
*AEROBIC exercises
*ALZHEIMER'S disease
*CLINICAL trials
*NOSOLOGY
*ANALYSIS of variance
*CARDIOPULMONARY fitness
*BLOOD plasma
*RESEARCH methodology
*OXYGEN consumption
*EXERCISE physiology
*COGNITION
*TREADMILLS
*BLOOD collection
*PSYCHOLOGICAL tests
*NEUROPSYCHOLOGICAL tests
*PRE-tests & post-tests
*T-test (Statistics)
*EXERCISE intensity
*HEART beat
*LACTATES
*REPEATED measures design
*BRAIN-derived neurotrophic factor
*VASCULAR endothelial growth factors
*DATA analysis
*DATA analysis software
*BLOOD
Subjects
Details
- Language :
- English
- ISSN :
- 0361073X
- Volume :
- 49
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Experimental Aging Research
- Publication Type :
- Academic Journal
- Accession number :
- 161062700
- Full Text :
- https://doi.org/10.1080/0361073X.2022.2048586