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Identification of the Major Degradation Pathways of Selumetinib.
- Source :
-
Pharmaceutics . Dec2022, Vol. 14 Issue 12, p2651. 11p. - Publication Year :
- 2022
-
Abstract
- Selumetinib is administered orally in capsule form and is indicated for the treatment of neurofibromatosis. To facilitate dosage adjustments, liquid preparations, such as solutions or suspensions, are to be developed. This led, first, to determine the stability profile of soluble or dispersed selumetinib and, secondly, to look for ways to stabilize the active substance. The degradation kinetics of selumetinib as a function of stress conditions were determined and compared. The degradation products were detected and identified by LC-HRMSn. In solution, selumetinib is sensitive to oxidation and degrades by photooxidation. In both cases, the side chain represented by the oxoamide group is concerned, leading to the formation of an amide derivative for the first case and an ester derivative for the second. The identification of such degradation mechanisms allowed us to study, in a targeted way, processes aiming at stabilizing the active molecule. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESTER derivatives
*PHOTOOXIDATION
*PROTEIN kinase inhibitors
*DRUG dosage
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 14
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 161038666
- Full Text :
- https://doi.org/10.3390/pharmaceutics14122651