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Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments.

Authors :
Rehman, Muneeb U.
Sehar, Nouroz
Dar, Nawab John
Khan, Andleeb
Arafah, Azher
Rashid, Summya
Rashid, Shahzada Mudasir
Ganaie, Majid Ahmad
Source :
Neuroscience & Biobehavioral Reviews. Jan2023, Vol. 144, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease (PD), and Huntington disease (HD) represent a major socio-economic challenge in view of their high prevalence yet poor treatment outcomes affecting quality of life. The major challenge in drug development for these NDs is insufficient clarity about the mechanisms involved in pathogenesis and pathophysiology. Mitochondrial dysfunction, oxidative stress and inflammation are common pathways that are linked to neuronal abnormalities and initiation of these diseases. Thus, elucidating the shared initial molecular and cellular mechanisms is crucial for recognizing novel remedial targets, and developing therapeutics to impede or stop disease progression. In this context, use of multifunctional compounds at early stages of disease development unclogs new avenues as it acts on act on multiple targets in comparison to single target concept. In this review, we summarize overview of the major findings and advancements in recent years focusing on shared mechanisms for better understanding might become beneficial in searching more potent pharmacological interventions thereby reducing the onset or severity of various NDs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01497634
Volume :
144
Database :
Academic Search Index
Journal :
Neuroscience & Biobehavioral Reviews
Publication Type :
Academic Journal
Accession number :
161034553
Full Text :
https://doi.org/10.1016/j.neubiorev.2022.104961