CTHRC1+ fibroblasts are stimulated by macrophage‐secreted SPP1 to induce excessive collagen deposition in keloids.

Dear Editor, Fibrosis is characterized by fibroblast dysfunction and excessive deposition of cell-matrix that affect the normal functioning of the original tissue or organ.[1] The pathogenesis of keloids is complex and remains elusive. Fibroblasts interacted with endothelial cells via I ACKR1 i , while multiple chemokines ( I CXCL2 i , I CCL3L3 i ) secreted by myeloid cells interacted with I DPP4 i in fibroblasts (Figure 4D). (F) Interaction of macrophages and fibroblasts based on molecular patterns indicated that macrophages interact with fibroblasts via SPP1. CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. [Extracted from the article]