Clinical commentary about foreign body complications over 20 years after polymethyl‐methacrylate face implants and control of late sequelae with Polynucleotides Highly Purified Technology (PN‐HPT®).

Introduction: Mainly in the past, foreign body complications, including granuloma, were pretty frequent after semi‐permanent polymethyl‐methacrylate (PMMA) implants. Results: The authors describe a twenty‐year history of recurring post‐PMMA complications interspersed by long uneventful years, with acute edematous side effects evolving into unpleasant skin dystrophia with persistent cutis laxa. The case report also discusses a simple clinical algorithm to discriminate among foreign body complications with particular attention to granulomas. Conclusions: The authors conclude by discussing the benefits of the anti‐dystrophic treatment with natural‐origin remodeling PN‐HPT® (Polynucleotides Highly Purified Technology). [ABSTRACT FROM AUTHOR]