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Detection of interaction between an RNA aptamer and its target compound in living human cells using 2D in-cell NMR.
- Source :
-
Chemical Communications . 1/4/2023, Vol. 59 Issue 1, p102-105. 4p. - Publication Year :
- 2023
-
Abstract
- We introduced an isotopically labeled RNA aptamer for HIV-1 Tat prepared by E. coli transcription into HeLa cells. We successfully recorded the first heteronuclear 2D in-cell NMR spectra, which makes it possible to study the interaction of the RNA aptamer with argininamide in living human cells with higher resolution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 59
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 160930892
- Full Text :
- https://doi.org/10.1039/d2cc05576g