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Prognostic factors and outcomes of infant acute lymphoblastic leukemia (ALL), hypodiploid ALL, and mixed-phenotype acute leukemia (MPAL) in Canada: a report from CYP-C.
- Source :
-
Leukemia & Lymphoma . Dec2022, Vol. 63 Issue 13, p3208-3216. 9p. - Publication Year :
- 2022
-
Abstract
- The epidemiology of infant acute lymphoblastic leukemia (ALL), hypodiploid ALL, and mixed-phenotype acute leukemia (MPAL) in Canada is unknown. The main objective was to describe the prevalence, prognostic factors, and outcomes of three rare and high-risk ALL subtypes in Canada. This is a retrospective study using the Cancer in Young People-Canada (CYP-C) database. Event-free survival (EFS) and overall survival (OS) were described by the Kaplan–Meier method and compared using the log-rank test. Among 2626 children aged 0–14 years diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) between 2001 and 2018, 227 (8.6%) patients were identified to be infant ALL (n = 139), hypodiploid ALL (n = 43), or MPAL (n = 45). The 5-year EFS/OS was significantly worse in the infant ALL subgroup compared to that of hypodiploid ALL and MPAL. For the entire cohort, presenting White blood cells (WBCs) ≥50 × 109/L was independently associated with worse EFS/OS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LYMPHOBLASTIC leukemia
*ACUTE leukemia
*PROGNOSIS
*INFANTS
*LEUCOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 63
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 160870915
- Full Text :
- https://doi.org/10.1080/10428194.2022.2118536