Intertwined relationship among ROS, mitochondria and APOE4 during the onset of Alzheimer's disease.

The Alzheimer's disease, a kind of dementia recognized by the National Institute of Neurological Disorders and Stroke as a "progressive, neurodegenerative disease", is destroying the life of around 50 million people worldwide. Multiple biomarkers have been detected in relation to AD, with a current emphasis in figuring out how the accumulation of Aβ can be affected by the interplay of ROS, mitochondria, and APOE4. While ROS arises from highly chemicals formed by oxygen and mitochondria being the energy center of human body, APOE4 is a newly-targeted gene connected with AD. This review tries to go through the mechanisms mediated by the three potential factors mentioned above. As the mechanisms count considerably in the cause of AD, the related drugs and therapeutic methods aimed to mitigate the influence brought by the three factors will also be summarized. [ABSTRACT FROM AUTHOR]