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Metformin Can Be Safely Used in Patients Exposed to Contrast Media: A Systematic Review and Meta-Analysis.
- Source :
-
Cardiology . 2022, Vol. 147 Issue 5/6, p469-478. 10p. - Publication Year :
- 2022
-
Abstract
- Background: There have been few studies published on the use of contrast media (CM) in metformin-treated patients. In this study, we conducted a systematic review and meta-analysis to investigate the relationship between metformin and contrast-induced acute kidney injury (CI-AKI). Methods: A comprehensive search of the Medline, PubMed, Embase, and Web of Science databases for literature on associations between metformin use and CI-AKI incidence was conducted. The pooled odds ratio (OR), or relative risk, as well as the corresponding 95% confidence intervals (CIs), was calculated to assess the relationship between metformin and CI-AKI risk as well as the incidence of lactic acidosis (LA). Results: In total, seven studies met our eligibility criteria on associations between metformin use and CI-AKI incidence, comprising 2,325 individuals, with 279 new cases of CI-AKI exposed to CM. The pooled analysis revealed no statistically significant increase in the risk of CI-AKI development in patients who used metformin continuously (random-effects OR: 1.15, 95% CI: 0.70–1.90, p = 0.57). No cases of LA that occurred during CM exposure were reported. Conclusion: Metformin can be safely used in patients with moderate renal impairment (eGFR ≥ 30 mL/min/1.73 m2) during CM exposure. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00086312
- Volume :
- 147
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 160823887
- Full Text :
- https://doi.org/10.1159/000527384