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Copper(I)‐Catalyzed Regioselective Tandem Cyanoalkylative Cyclization of 1,5‐Dienes with Cyclobutanone Oxime Esters.
- Source :
-
European Journal of Organic Chemistry . 12/6/2022, Vol. 2022 Issue 45, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- An effective strategy for construction of 1,5‐dihydro‐2H‐pyrrol‐2‐one scaffolds by a cascade of 1,5‐dienes with cyclobutanone oxime esters was developed. The reaction proceeded through radical addition, 5‐endo cyclization, and subsequent deprotonation, in which two new C−C bonds were formed. This protocol features excellent regioselectivity and a low‐cost catalyst, as well as broad substrate scope, which are expected to promote its potential applications in pharmacy and synthetic chemistry. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*ESTERS
*COPPER
*PROTON transfer reactions
*CATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2022
- Issue :
- 45
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 160676633
- Full Text :
- https://doi.org/10.1002/ejoc.202201091