PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa.

The article characterizes the metabolic pathway of 2-methylcitrate cycle in Pseudomonas aeruginosa and unveil that PmiR served as a receptor of 2-methylisocitrate (MIC) to govern bacterial virulence. It discusses that mutation of pmiR reduces bacterial survival in a mouse model of acute pneumonia infection and identifying Pseudomonas aeruginosa PmiR as an important metabolic sensor for regulating expression of bacterial virulence genes to adapt to the harsh environments.