Survival after minimally invasive radical hysterectomy without using uterine manipulator for early‐stage cervical cancer: A systematic review and meta‐analysis.

Background: Minimally invasive radical hysterectomy has been reported to increase the risk of cancer relapse and death compared with open surgery in women with early‐stage cervical cancer. The use of a uterine manipulator is considered one of the risk factors. Objectives: To investigate whether women with early‐stage cervical cancer treated with minimally invasive radical hysterectomy without using uterine manipulator have oncological outcomes similar to those of open surgery. Search strategy: Searches were performed in MEDLINE, Embase and CENTRAL from their inception until 31 March 2022. Selection criteria: Inclusion criteria were: (1) randomised controlled trials or observational cohort studies published in English, (2) studies comparing minimally invasive radical hysterectomy without using a uterine manipulator with open radical hysterectomy in women with early‐stage cervical cancer, and (3) studies comparing survival outcomes. Data collection and analysis: Two authors independently conducted data extraction and assessed study quality. We calculated the hazard ratios (HR) and the 95% confidence intervals (CI) using the inverse variance approach for survival outcome. Main results: Six observational studies with 2150 women were included. The minimally invasive surgery group had a significantly higher risk of cancer relapse compared with open surgery group (HR 1.55, 95% CI 1.15–2.10). Conclusions: Minimally invasive radical hysterectomy without using a uterine manipulator resulted in an inferior recurrence‐free survival compared with open radical hysterectomy in the treatment of women with early‐stage cervical cancer. [ABSTRACT FROM AUTHOR]