Recent advances in disease diagnosis based on electrochemical-optical dual-mode detection method.

The electrochemical method is commonly applied in diagnosing and monitoring diseases. When used in conjunction with optical disease detection systems, it can broaden the detection range, lower the limit of detection and create mutual confirmation. Utilizing the electrochemical-optical dual-mode detection method for disease diagnosis is non-invasive, low-cost, easy-to-use, efficient and accurate compared with the traditional single-mode method. This paper reviews the reports of electrochemistry and optical methods combined in recent years, such as colorimetry, fluorescence, Surface Enhanced Raman Spectroscopy (SERS), surface plasmon resonance (SPR) and spectroelectrochemistry. We cover researches on several electrochemical-optical dual-mode detection methods for identifying disease markers, including biochemistry, cancer, infection, cardiovascular and cerebrovascular disease, and neurological diseases as well. These studies demonstrate the feasibility of electrochemical-optical dual-mode detection and its broad application prospects in the field of disease detection. This paper reviews the popular schemes of electrochemical dual-mode detection in disease diagnosis recently. First of all, five electrochemical dual-mode disease detection are discussed, such as electrochemical-colorimetry mode, electrochemical-fluorescence mode, electrochemical-SERS mode, electrochemical-SPR mode and electrochemical-microfluidics mode. Secondly, we investigate the schemes of various electrochemical dual-mode detection methods for the detection of different types of diseases, such as biochemical detection, cancer detection, infection detection, detection of cardiovascular and cerebrovascular and neurological disease detection. Finally, alternative electrochemical dual-mode detection methods are compared. We also evaluate their detection qualities across a variety of disorders and recommend research avenues that researchers may favor in the future. [Display omitted] • Introducing the research progress of electrochemical-optical dual-mode detection in different kinds of diseases. • Stating the excellent schemes of combining electrochemistry with different kinds of optical methods in disease detection. • An in-depth analysis of the benefits and drawbacks of several electrochemical-optical dual-mode detection methods. • The future prospect of different electrochemical-optical dual-mode detections in disease diagnosis are discussed. [ABSTRACT FROM AUTHOR]