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2 型糖尿病患者血清尿酸、胱抑素 C、半乳糖凝集素 -3、丝氨酸蛋白酶抑制剂 B1 与血糖及颈动脉粥样硬化的关系研究.

Authors :: 费朝霞
 李红
 丁明罡
 韩洁
Source :: Progress in Modern Biomedicine. Oct2022, Vol. 22 Issue 20, p3951-3955. 5p.
Publication Year :: 2022
Abstract: Objective: To study the relationship between serum uric acid (UA), cystatin C (CysC), galectin 3 (Gal-3), serine protease inhibitor B1 (Serpin B1) and blood glucose and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM). Methods: 110 patients with T2DM who were treated in the Department of Endocrinology of Qingdao Hospital of Traditional Chinese Medicine from April 2020 to April 2022 selected, and they were divided into 36 cases in CAS group and 74 cases in non CAS group according to the presence or absence of CAS. The levels of serum UA, CysC, Gal-3 and Serpin B1 were detected and compared between the two groups. Pearson/Spearman correlation coefficient was used to analyze the correlation between the levels of serum UA, CysC, Gal3, Serpin B1 and blood glucose indexes in patients with T2DM. The basic data of patients were collected, and the influencing factors of CAS in patients with T2DM were analyzed by multivariate Logistic regression. The levels of serum UA, CysC, Gal-3 and Serpin B1 in CAS group were significantly higher than those in non CAS group (P<0.05). The average age of CAS group was higher than that of non CAS group, and the proportion of patients with smoking history, fasting blood glucose, glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR) and low density lipoprotein cholesterol (LDL-C) were higher than those in non CAS group (P<0.05). Correlation analysis showed that the levels of serum UA, CysC, Gal-3 and Serpin B1 in patients with T2DM were positively correlated with HbA1c and HOMA-IR (P<0.05). Multivariate Logistic regression analysis showed that older age, higher levels of HbA1c, HOMA-IR, serum UA, CysC, Gal3 and Serpin B1 were the risk factors of CAS in patients with T2DM (P<0.05). Elevated levels of serum UA, CysC, Gal3 and Serpin B1 are closely associated with blood glucose level of patients with T2DM, and it is also the influencing factor of CAS in patients with T2DM. [ABSTRACT FROM AUTHOR]