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Are peanut oral food challenges still useful? An evaluation of children with suspected peanut allergy, sensitization to Ara h 2 and controlled asthma.
- Source :
-
Allergy, Asthma & Clinical Immunology . 11/30/2022, Vol. 18 Issue 1, p1-8. 8p. - Publication Year :
- 2022
-
Abstract
- Background: Sensitization to Ara h 2 has been proposed as a promising biological marker for the severity of peanut allergy and may reduce the need for oral food challenges. This study aimed to evaluate whether peanut oral food challenge is still a useful diagnostic tool for children with suspected peanut allergy and an elevated level of Ara h 2-specific IgE. Additionally, we assessed whether well-controlled asthma is an additional risk for severe reactions. Methods: A retrospective analysis of 107 children with sensitization to Ara h 2-specific IgE (> 0.35 kU/l) undergoing open peanut challenges during 2012–2018 in the Tampere University Hospital Allergy Centre, Finland. Results: Of the 107 challenges, 82 (77%) were positive. Serum levels of Ara h 2 -sIgE were higher in subjects with a positive challenge than in those who remained negative (median 32.9 (IQR 6.7–99.8) vs. 2.1 (IQR 1.0–4.9) kU/l), p < 0.001) but were not significantly different between subjects with and without anaphylaxis. No correlation was observed between the serum level of Ara h 2-sIgE and reaction severity grading. Well-controlled asthma did not affect the challenge outcome. Conclusions: Elevated levels of Ara h 2-specific IgE are associated with a positive outcome in peanut challenges but not a reliable predictor of reaction severity. Additionally, well-controlled asthma is not a risk factor for severe reactions in peanut challenges in children with sensitization to Ara h 2. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEANUT allergy
*PEANUTS
*ASTHMA
*BIOMARKERS
*IMMUNOGLOBULIN E
Subjects
Details
- Language :
- English
- ISSN :
- 17101484
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Allergy, Asthma & Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 160503906
- Full Text :
- https://doi.org/10.1186/s13223-022-00743-6