OS EFEITOS ANTI-INFLAMATÓRIOS DA MELATONINA NA OBESIDADE: UMA REVISÃO DA LITERATURA.

Introduction: Obesity is a disease of multifactorial etiology responsible for generating a state of subclinical chronic inflammation. Melatonin, a hormone physiologically produced by the pineal gland, has been widely studied for its antiinflammatory effect in several diseases. Objective: To analyze the anti-inflammatory effects of melatonin supplementation in the treatment of obesity. Materials and Methods: This narrative review was carried out through a bibliographic survey, using the digital databases Pubmed, Scielo, Lilacs, Google Scholar and CAPES Periodicals. Results: A double-blind randomized study evaluated 44 women with obesity, who were randomly divided into a group that used melatonin (n=22) and another group that used placebo (n=22). It was observed that only the group of patients who used melatonin showed a significant reduction in the serum concentrations of inflammatory markers such as TNF alpha, IL-6, hsCRP and MDA. Another randomized double-blind study analyzed 30 patients with obesity who were randomized into 2 groups, group 1 (n=15) received 10 mg of melatonin and group 2 (n=15) received placebo. With melatonin supplementation, concentrations of adiponectin omentin 1 and GPx (antioxidant enzyme) increased significantly, while levels of MDA (marker of oxidative stress) decreased significantly. Conclusion: Although clinical studies on this topic are scarce and the existing ones have a small sample number, the results so far have demonstrated the effectiveness of melatonin in counterbalancing the deleterious effects of excess adipose tissue. [ABSTRACT FROM AUTHOR]