EFEITOS DA ADMINISTRAÇÃO DE GLUTAMATO MONOSSÓDICO (MSG) EM RATAS WISTAR LACTANTES SOBRE O METABOLISMO DOS FILHOTES.

The worldwide prevalence of obesity has been increasing in recent decades, being characterized as a true global epidemic. Monosodium glutamate is capable of injuring neurons of the central nervous system sensitive to this amino acid through excitation, triggering obesity as a result of a multifactorial neuroendocrine disorder, resulting from the injury of nervous centers linked to endocrine regulation, which occurs at an early stage of development. The objective of this work was to evaluate the effects of administration of monosodium glutamate (MSG) in lactating Wistar rats on the metabolism of the offspring. For this, lactating rats were treated with monosodium glutamate and received orally (0.9% solution) daily doses of MSG. After delivery, the pups (females) were divided into 2 groups of 8 animals, being a control group (C) pups of control rats and a MSG lactation group (ML), pups of rats treated with monosodium glutamate. The evolution of body weight was evaluated; liver weight (FIG), retroperitoneal white adipose tissue (RET) and parametrial white adipose tissue (PAR); serum levels of glucose, triglycerides, total cholesterol and HDL-Cholesterol. Our results demonstrated greater body weight gain, greater weight of white adipose tissue RET and PAR, greater serum concentrations of glucose, triglycerides and total cholesterol in animals whose dams were treated with MSG. No statistical differences were found in FIG weight and HDLCholesterol concentration. We can conclude that the treatment of lactating rats with monosodium glutamate altered the metabolism of the offspring, promoting obesity and dyslipidemia. [ABSTRACT FROM AUTHOR]