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The enhanced antibacterial effect of BNNS_Van@CS/MAO coating on Mg alloy for orthopedic applications.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Jan2023, Vol. 221, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- The development of multifunctional Mg-based active implants with controllable degradation and antibacterial capabilities has become a hotspot in the research field of biodegradable metallic materials. To this end, a BN nanosheets (BNNS) _ vancomycin (Van) @ chitosan (CS) nanocomposite coating containing two antibacterial components (BNNS and Van) was prepared on Mg alloys via a micro-arc oxidation (MAO) pre-treatment combined with following electrodeposition. The related characterizations of the coating show that the composite coating has a high roughness, hydrophobicity and fair corrosion resistance. In vitro antibacterial experiments show that the BNNS_Van@CS/MAO composite coating have obvious inhibitory effect on the growth of both E. coli and S. aureus. The antibacterial effect of the BNNS_Van@CS/MAO composite coating was attributed to the synergistic effect of CS, BNNS and Van. This study provides a valuable surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance and antibacterial properties. [Display omitted] • BNNS@CS-loaded vancomycin composite coatings were prepared on ZE21C alloy. • BNNS_Van@CS/MAO coating provides an effective protection for the ZE21C alloy. • BNNS_Van@CS/MAO coating has good antibacterial effect against E.coli and S.aureus. • BNNS@CS coating and vancomycin have synergistic antibacterial effects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 221
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 160397505
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2022.112971