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Uso tópico de ácido tranexámico en artroplastías totales de cadera: análisis retrospectivo de sus ventajas.
- Source :
-
Acta Ortopédica Mexicana . mar/abr2022, Vol. 36 Issue 2, p110-115. 6p. - Publication Year :
- 2022
-
Abstract
- Introduction: intravenous (IV) tranexamic acid (TXA) has shown its usefulness to prevent postsurgical anemia, but few studies have analyzed its topical administration. Seven years ago, we implemented a new topical administration (moistening three gauzes with 1.5 g of TXA) in our primary total hip arthroplasties (THA). The objective of this study was to compare blood loss, hospital stay and complications without the use of TXA, topical use or 10 mg/kg IV plus topical. Material and methods: consecutive retrospective series of 274 patients undergoing CTA (mean 70 years [59-76], 59% women) operated from 2014 to 2019. Loss of hemoglobin and hematocrit, blood transfusions, hospital stay, thromboembolic complications were compared and 30-day mortality among three groups: non-tranexamic (44.2%), topical (45.6%), topical + IV (9.9%). Results: after 24 and 48 hours, hemoglobin and hematocrit decreased less (p < 0.05) in patients treated with TXA (topical and/or IV). Blood transfusion was required in 32% of patients without TXA, 12% of those treated with topical TXA only (RR = 3.24 [95% CI: 1.69-6.20]), and 0% of patients who received IV TXA (p = 0.005) (RR = 4.07 [95% CI: 2.14-7.48]). Hospital stay was reduced three days with TXA (p < 0.001). We have not observed any adverse effects related to TXA. Conclusions: the use of TXA in CTA significantly reduces anemia, transfusions and hospital stay without increasing complications. Isolated topical TXA (hemostatic pads) is less effective than topical IV + topical use, but both significantly improve anemia, transfusions, and hospital stay compared to no use. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Spanish
- ISSN :
- 23064102
- Volume :
- 36
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Ortopédica Mexicana
- Publication Type :
- Academic Journal
- Accession number :
- 160383930
- Full Text :
- https://doi.org/10.35366/108126