The Relationship between COVID-19 Suspected Patient's Coagulation and Platelet Parameters and Polymerase Chain Reaction Results.

Objective: This study aims to investigate the relationship between prothrombin time (PT), activated partial thromboplastin time (aPTT), INR (International Normalized Ratio), and Ddimer levels, platelet (PLT) levels at hospital admission, and positivity or negativity of Polymerase Chain Reaction (PCR) test results in patients with suspected coronavirus disease-19 (COVID-19) followed at COVID-19 services. Methods: This study was performed on 238 patients with the prediagnosis of COVID-19, all patients are hospitalised in Samsun city at our hospital between 11 March 2020-30 May 2020. According to COVID-19 PCR test results, PCR test negative 119 individua and PCR test positive 119 patients were included in the study. PT, aPTT, D-dimer, INR, and PLT levels were examined. Results: While PCR test negative individuals had a mean PT value of 11.46±0.86 sec, PCR test positive patients had a mean PT value of 12.97±3.65 sec (p<0.001). There was no significant difference in mean aPTT values of PCR test positive and negative patients. Whereas INR, D-dimer increased significantly in PCR test positive patients. PLT value decreased from a mean value of 266.75±71.36*109/L in PCR test negative patients to 241.18±96.64*109/L in PCR test positive patients (p=0.002). Conclusions: In our study, it was found that in patients who were admitted to hospital with COVID-19 suspicion and followed up in COVID-19 services, PT, D-dimer, INR, PLT values were important in detecting coagulopathy and thrombocytopenia in the group who were PCR positivity. [ABSTRACT FROM AUTHOR]