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New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas.
- Source :
-
Biochemistry (00062979) . Nov2022, Vol. 87 Issue 11, p1243-1251. 9p. - Publication Year :
- 2022
-
Abstract
- Memory formation is a complex process involving changes in the synaptic activity and gene expression encoding the insulin-like growth factors. We analyzed changes in the expression of genes encoding the insulin/insulin-like growth factors' proteins at the early period of learning in the CA1 region and dentate gyrus of the dorsal and ventral hippocampus in mice 1 hour after presentation of a new context (contextual fear conditioning) with and without negative reinforcement. It was found that in addition to changes in the expression of immediate early genes c-Fos (in all studied hippocampal fields) and Arc (in dorsal and ventral CA1, as well as in dorsal dentate gyrus), exposure to a new context significantly altered expression of the insulin receptor substrate 2 gene (Irs2) in dorsal CA1 and ventral dentate gyrus irrespectively of the negative reinforcement, which suggests participation of the insulin/IGF system in the early stages of neural activation during learning. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00062979
- Volume :
- 87
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Biochemistry (00062979)
- Publication Type :
- Academic Journal
- Accession number :
- 160295046
- Full Text :
- https://doi.org/10.1134/S0006297922110037