Algebraic Polynomial Based Topological Properties of Anti-Tumor Drug; Hyaluronic Acid-Doxorubicin (HAD).

Doxorubicin, a prominent anti-tumor agent obtained mainly for the diagnosis of breast and ovarian cancer, suffers tremendous disservices, such as poor solvency, some harmfulness and clear resistance by other tumor cells to the drug. The integration of doxorubicin with a bio-compatible substrate, such as hyaluronic acid, has been listed among the different systems suggested. In general, linking a bio-active material to a bio-compatible polymer provides various points of concern, such as improved solubilization of drugs, improved modification, specific restriction and regulated discharge. Several medical analyses have confirmed that the characteristics of medical drugs have a nearby connection with their atomic structure. Medication properties can be acquired by considering the atomic structure of relating drugs. The calculation of the topological index of a medication structure empowers researchers to have a superior comprehension of the physical science and bio-organic attributes of drugs. The algebraic polynomials play an important role in the computation of topological descriptor. In this paper, we evaluated M-polynomial and NM-polynomial with graphical representations of the structure of hyaluronic acid-doxorubicin (HAD) and then we have computed some degrees based and neighborhood degrees sum based topological indices from the expression of these polynomials which commonly used to study the pharmaceutical properties of drugs. [ABSTRACT FROM AUTHOR]