Evaluation of Total Antioxidant Capacity and Total Oxidant Status in Patients with COVID-19.

The COVID-19 is spreading rapidly over the globe disease. A deadly global pandemic of Coronavirus sickness (COVID-19) has caused significant morbidity and mortality in a number of locations. Oxidative stress appears to play a role in COVID-19. The goal of this casecontrol study was to compare the levels of total antioxidant capacity (TAC), total oxidant status (TOS), and lipid peroxidation products like malondialdehyde (MDA) in the serum of COVID-19 infection patients to a healthy control group, with a scientific interpretation of the results. The data was gathered from (90) participants who were classified into two categories: patients and controls. The CUPRAC procedure evaluates A spectrophotometric reader was used to determine the total oxidant status (TOS). With a p-value of 0.05, the results revealed that there were significant variations in TOS levels between the COVID -19 and control groups (0.009). TAC levels differed significantly between the patient and control groups, with a p-value of (0.012), while TAC levels in the patient group dropped. (1.24±0.15), compared to (1.55±0.31) in the control group; moreover, oxidative stress is higher in covid-19, with MDA levels of (6.45±1.14), compared to (3.22±0.69) in the control group, with a significant p-value (0.002). Conclusions: Based on the data, it seems that levels of (MDA) are higher in the COVID-19 group than in the control group due to Infection with a virus and a storm of the immune system In addition to acting as an antiinflammatory mediator, (MDA) is a biomarker for lipid peroxidation, and an increase in free radicals causes oxidative stress, resulting in an increase in (MDA) levels. (TAC) levels were also lower in patients than in the control group, and our findings revealed that patients had higher (TOS) levels than the control group. [ABSTRACT FROM AUTHOR]