Study of association between Qrisk2 score, components of metabolic syndrome and oxidative stress in subjects with metabolic risk factors.

Introduction: The most fearful outcome of metabolic syndrome is cardiovascular events leading to morbidity and mortality. Q risk2 score was developed by physicians working in UK National Health Service to estimates the risk of cardiovascular disease incidence over the next 10 years. Qrisk2 score <10% indicates mild risk, 10-20-% moderate risk, >20% high risk of CVD. MRF are progressive inflammatory processes leading to rise in serum hsCRP and depletion of GSH, indicating increased oxidative stress which has been associated with higher risk of CVD. Therefore, this study has been designed to study the association of QRISK2 score with oxidative stress in apparently healthy adults at metabolic risk. Material and Methodology: Subjects of both genders, age between 25 to 45 years were enrolled as per inclusion & exclusion criteria and detailed clinical history was taken. All candidates were subjected to Anthropometry (height, weight, BMI, Waist Circumference), BP measurements, lipid profile, GSH, hsCRP and fasting blood sugar. Qrisk2 score was calculated by online calculator (https://qrisk.org/2017/) All subjects were screened for metabolic risk factors (MRF). Subjects without any MRF were put into Group A and those with any MRF were kept in Group B. All recruited subjects were divided into low-risk group (Qrisk2 score <10%) & highrisk group (Qrisk2 score >10%). Then, various components of metabolic syndrome and oxidative stress will be compared in both groups. Results: In this study, weight, BMI, BP, TG, LDL, total cholesterol, fasting blood sugar, GSH and hsCRP was statistically significantly higher in subjects with MRF. Smoking, diabetes, HTN and obesity was more common in high Qrisk2 score group (Qrisk2 score >10). Systolic BP was statistically significantly higher in high Qrisk2 score group but difference in diastolic BP was not statistically significant. TG, LDL, total cholesterol, fasting blood sugar, serum GSH and hsCRP was statistically higher in high Qrisk2 score group whereas, HDL was statistically significantly lower. Conclusion: Smoking, diabetes, HTN and obesity increases the future risk of CVD and systolic BP is more important than diastolic BP. We also observed high Qrisk 2 score is associated with increased oxidative stress. [ABSTRACT FROM AUTHOR]