Back to Search Start Over

Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans.

Authors :
Yerevanian, Armen
Murphy, Luke M.
Emans, Sinclair
Zhou, Yifei
Ahsan, Fasih M.
Baker, Daniel
Li, Sainan
Adedoja, Adebanjo
Cedillo, Lucydalila
Stuhr, Nicole L.
Gnanatheepam, Einstein
Dao, Khoi
Jain, Mohit
Curran, Sean P.
Georgakoudi, Irene
Soukas, Alexander A.
Source :
Aging Cell. Nov2022, Vol. 21 Issue 11, p1-17. 17p.
Publication Year :
2022

Abstract

Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin transporter 1 (rft‐1) promotes metabolic health by reducing intracellular flavin concentrations. Knockdown of rft‐1 significantly increases lifespan in a manner dependent upon AMP‐activated protein kinase (AMPK)/aak‐2, the mitochondrial unfolded protein response, and FOXO/daf‐16. Riboflavin depletion promotes altered energetic and redox states and increases adiposity, independent of lifespan genetic dependencies. Riboflavin‐depleted animals also exhibit the activation of caloric restriction reporters without any reduction in caloric intake. Our findings indicate that riboflavin depletion activates an integrated hormetic response that promotes lifespan and healthspan in C. elegans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14749718
Volume :
21
Issue :
11
Database :
Academic Search Index
Journal :
Aging Cell
Publication Type :
Academic Journal
Accession number :
160178006
Full Text :
https://doi.org/10.1111/acel.13718