Targeting the immune system towards novel therapeutic avenues to fight brain aging and neurodegeneration.

The incidence of age‐related dementia is growing with increased longevity, yet there are currently no disease‐modifying therapies for these devastating disorders. Studies over the last several years have led to an evolving awareness of the role of the immune system in supporting brain maintenance and repair, displaying a diverse repertoire of functions while orchestrating the crosstalk between the periphery and the brain. Here, we provide insights into the current understanding of therapeutic targets that could be adopted to modulate immune cell fate, either systemically or locally, to defeat brain aging and neurodegeneration. [ABSTRACT FROM AUTHOR]