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MicroRNAs' Crucial Role in Salivary Gland Cancers' Onset and Prognosis.

Authors :
Bocchetti, Marco
Grisolia, Piera
Melisi, Federica
Ferraro, Maria Grazia
De Luca, Pietro
Camaioni, Angelo
Falco, Michela
Abate, Marianna
Misso, Gabriella
Alfano, Roberto
Accardo, Nunzio
Oliva, Flavia
Cossu, Alessia Maria
Caraglia, Michele
Scrima, Marianna
Ricciardiello, Filippo
Source :
Cancers. Nov2022, Vol. 14 Issue 21, p5304. 12p.
Publication Year :
2022

Abstract

Simple Summary: Salivary gland cancers are incredibly heterogeneous, both in the physical onset and in the aggressiveness. Setting up a novel diagnostic and prognostic detection method based on the noninvasive microRNAs' profiling might represent a goal for the clinical management of those particular malignancies, saving precious time for the patients. Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726694
Volume :
14
Issue :
21
Database :
Academic Search Index
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
160147342
Full Text :
https://doi.org/10.3390/cancers14215304