Vulvar Malignant Melanoma: A Narrative Review.

Simple Summary: Vulvar melanoma (VM) is a rare and fatal disease. Knowledge of this disease is poor and, consequently, so is knowledge of the prognosis. Our aim was to collect evidence on VM with particular attention to its molecular profile and related clinical and therapeutic implications. Malignant melanoma is a fatal disease that affects all skin sites. Among these, vulvar melanoma (VM) is a rare gynecological condition that accounts for 5% of all vulvar neoplasms. VM primarily affects older Caucasian women and its relationship to sun exposure is undefined. Diagnosis is defined by biopsy but many clinical, dermatoscopic, and confocal microscopic features can guide doctors. The molecular profile is characterized by the KIT mutation, revealed by all of the technologies that are used (classical sequencing, next-generation sequencing, and immunohistochemical staining). BRAF and NRAS mutations are also common in VM. All of these mutations are possible therapeutic targets. Today, surgery remains the first treatment choice for primary VM. The role of neoadjuvant and adjuvant therapy is scarce and the treatment of relapses is widely debated. [ABSTRACT FROM AUTHOR]