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Association between PTCH1 and RAD54B Single-Nucleotide Polymorphisms and Non-syndromic Orofacial Clefts in the Northeast Population of Iran.
- Source :
-
Avicenna Journal of Medical Biotechnology . Oct-Dec2022, Vol. 14 Issue 4, p310-316. 7p. - Publication Year :
- 2022
-
Abstract
- Background: Non-Syndromic Cleft Lip with or without cleft Palate (NSCL/P) is a common developmental disorder of the head and neck with a multifactorial etiology. The current study aimed to evaluate the potential association of PTCH1 (rs10512248) and RAD54B (rs12681366) polymorphisms with NSCL/P in the Northeast Iranian population. Methods: In the present study, blood samples were taken from 122 subjects with NSCL/P and 161 healthy controls. Polymerase Chain Reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) were used to conduct genotyping of single-nucleotide polymorphisms. Results: Although differences were observed between cases and controls in rs10512248 and rs12681366, our data did not support a significant association of these polymorphisms with NSCL/P in our population. Conclusion: Our findings suggest that polymorphisms of rs10512248 and rs12681366 may not be potential risk factors for NSCL/P in the Northeast Iranian population due to the multifactorial and multiethnicity characteristics of some genes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STATISTICAL significance
*STATISTICS
*CONFIDENCE intervals
*DNA
*CROSS-sectional method
*ELECTROPHORESIS
*CLEFT palate
*GENETIC polymorphisms
*QUANTITATIVE research
*CLEFT lip
*NUCLEOTIDES
*T-test (Statistics)
*CHI-squared test
*GENOTYPES
*DATA analysis software
*ODDS ratio
*LOGISTIC regression analysis
*POLYMERASE chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 20082835
- Volume :
- 14
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Avicenna Journal of Medical Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 160121753
- Full Text :
- https://doi.org/10.18502/ajmb.v14i4.10486