表皮生长因子受体抑制剂相关皮肤不良反应分期辨治思路探析.

Epidermal growth factor receptor inhibitors(EGFRIs) improve the survival rate of patients with EGFR-mutated non-small cell lung cancer significantly, but may simutaneously cause a series of adverse dermatological events. In traditional Chinese medicine(TCM) theory, EGFRIs could be classified as of dryness-heat nature that injures yin, therefore the adverse dermatological events are caused by heat-toxin of EGFRIs. Heat underpins the whole process of EGFR-mutated non-small cell lung cancer, and the disease location is the lung. The whole course of the disease can be divided into three stages, including wind-heat pattern combined with dampness-heat at the initial stage, yin deficiency and blood dryness pattern at the middle stage, and pattern of dual yin-yang deficiency at the advanced stage. Therefore, in the treatment of EGFRIs-related adverse dermatological events, on the basis of clearing heat, the therapeutic method differ in different stages, i. e. dispelling wind and eliminating dampness, nourishing yin and blood, as well as nourishing the spleen and kidney at the initial, middle, and advanced stages respectively. The formulae include Zhiyang Pingfu(Itch-relieving and Skin-soothing) Formula, Zizao Yangrong Tang(Dryness-relieving and Skin-Nourishing Decoction), Jingui Shenqi Wan(Golden Cabinet’s Kidney Qi Pill) and so on. [ABSTRACT FROM AUTHOR]