Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression.

The article presents a developmental neuroscience research on how tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression. Topics include critical role for the genetic and cellular niche environment in neural stem cell behavior; and , cortical astrocyte production and maturation is cell-autonomously controlled by PRC2-dependent transcriptional regulation.