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Non-criteria manifestations in the presence of antiphospholipid antibodies in a paediatric cohort.
- Source :
-
Rheumatology . Nov2022, Vol. 61 Issue 11, p4465-4471. 7p. - Publication Year :
- 2022
-
Abstract
- Objective To identify the variables associated with the development of non-criteria manifestations in the presence of antiphospholipid antibodies (aPLs) in a paediatric cohort. Methods Multicentric historical cohort study of children under the age of 18 years to determine thrombotic events (TEs) and non-criteria manifestations in the presence of aPL. Results Eighty-two children were included; 8.5% had at least one TE and 69.5% at least one non-criteria manifestation. Of them, 96.5% did not associate TEs. Haematological manifestations were the most frequent (43.65%), followed by cutaneous (22%), neurological (15.9%) and cardiac (4.9%) events. The most frequent aPLs were: 77.8% LA; 42.7% aCL and 41.5% aβ2GP. The positivity rate was: 64.6% simple, 18.3% double and 17.1% triple. ANA positivity was 68.1%. A bivariate analysis revealed that children with IgM aCL+, IgM aβ2GP+, ANA+, an SLE diagnosis or the absence of TEs had a significantly higher percentage of non-criteria manifestations (P  <0.05). The logistic regression showed family history of autoimmune diseases [odds ratio (OR) 4.26, 95% CI: 0.8, 22.2, P  =0.086] and the absence of TEs (OR 17.18, 95% CI: 1.2, 244.6, P  =0.03) as independent risk factors of developing non-criteria manifestations. An SLE diagnosis, aPL profile and ANA+ were not identified. Conclusion Non-criteria manifestations were more frequent than TEs. A positive family history of autoimmune diseases and the absence of TEs were associated with a higher risk of developing non-criteria manifestations. Therefore, their inclusion as APS classification criteria should be considered in order to get an improved prognosis in the paediatric population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOSIS risk factors
*AUTOANTIBODIES
*RESEARCH
*CARDIOVASCULAR diseases risk factors
*STATISTICS
*IMMUNOGLOBULINS
*CONFIDENCE intervals
*ANTIPHOSPHOLIPID syndrome
*CUTANEOUS manifestations of general diseases
*AUTOIMMUNE diseases
*RISK assessment
*NEUROLOGIC manifestations of general diseases
*BLOOD diseases
*DESCRIPTIVE statistics
*GLYCOPROTEINS
*PHOSPHOLIPIDS
*LOGISTIC regression analysis
*ODDS ratio
*LONGITUDINAL method
*FAMILY history (Medicine)
*DISEASE risk factors
*DISEASE complications
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 61
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 160000767
- Full Text :
- https://doi.org/10.1093/rheumatology/keac070