Cross Talk opposing view: Animal models of epilepsy are more useful than human tissue‐based approaches.

Keywords: animal models; epilepsy; epileptogenesis; human tissue; Seizure EN animal models epilepsy epileptogenesis human tissue Seizure 4575 4578 4 11/03/22 20221101 NES 221101 Epilepsy and models Epilepsy is one of the most common severe neurological diseases, affecting up to 70 million people worldwide (Ngugi et al., 2010). Cross Talk opposing view: Animal models of epilepsy are more useful than human tissue-based approaches Here, we argue that, despite advances in human tissue models, animal models of epilepsy remain more useful for interrogating basic mechanisms and novel therapeutics in epilepsy. Co-morbidities and non-seizure aspects of epilepsy Whilst epilepsy has classically been most closely associated with seizures, it is increasingly recognised that co-morbidities can include challenges with memory, sleep, and mental health (Mula et al., 2021). [Extracted from the article]