Back to Search
Start Over
Hepatitis C Virus Coinfection in People With Human Immunodeficiency Virus in Iran: A Systematic Review and Meta-Analysis.
- Source :
-
Open Forum Infectious Diseases . Oct2022, Vol. 9 Issue 10, p1-13. 13p. - Publication Year :
- 2022
-
Abstract
- Background Hepatitis C virus (HCV) coinfection is associated with higher mortality and morbidity in people with human immunodeficiency virus (PWH). Methods We aimed to characterize the epidemiology and factors associated with HCV coinfection among PWH in Iran. In this systematic review, we searched 3 English databases (MEDLINE, SCOPUS, Embase) and 2 Farsi databases (Scientific Information Database and Magiran) for studies that measured the prevalence of HCV coinfection among PWH, published between 2000 and January 1, 2021. We included studies with a minimum sample size of 5 PWH. Reviews, editorials, conference abstracts, theses, studies with no relevant data, and unclear serological assays were excluded. Results We summarized the HCV coinfection prevalence by random-effect meta-analysis and assessed the sources of heterogeneity by a meta-regression model. Of the 858 records identified, 69 eligible studies with 12 996 PWH were included. Overall, HCV coinfection prevalence was 64% (95% confidence interval [CI], 58–69). The prevalence was higher among older (mean age ≥35 years) PWH (69%; 95% CI, 64–74) and PWH who inject drugs (77%; 95% CI, 71–82). Furthermore, we found that coinfection was higher among studies conducted between 2000 and 2014 (67%; 95% CI, 59–75) versus 2015–2020 (57%; 95% CI, 50–64). Conclusions The prevalence of HCV coinfection is high in Iranian PWH, with significant geographical variations. Hepatitis C virus screening and treatment among PWH are warranted to avoid the future burden of HCV-related liver damage, cancer, and mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*HEPATITIS C virus
*MIXED infections
*SCIENCE databases
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Volume :
- 9
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Open Forum Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 159980158
- Full Text :
- https://doi.org/10.1093/ofid/ofac477