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Nanoarchitectonics of Indocyanine Green/Doxorubicin‐Loaded Hydroxyl Boron Nitride Nanosheets for Chemophotothermal Therapy.
- Source :
-
ChemPlusChem . Oct2022, Vol. 87 Issue 10, p1-7. 7p. - Publication Year :
- 2022
-
Abstract
- Biocompatible hydroxylated boron nitride nanosheets were effectively loaded with indocyanine green and doxorubicin using successive assembly. The indocyanine green/doxorubicin‐loaded hydroxyl boron nitride nanosheets (ICG/DOX@OH‐BNNS) integrated photothermal therapy and chemotherapy into a single nano vehicle. It had been confirmed that ICG/DOX@OH‐BNNS could produce reactive oxygen species and exhibit excellent photothermal effects and light‐triggered faster DOX release with NIR laser irradiation. On the other hand, the fluorescence of DOX in ICG/DOX@OH‐BNNS was also used for visualizing subcellular location. Compared with individual chemotherapy and photothermal therapy, the combined treatment of ICG/DOX@OH‐BNNS could synergistically induce the apoptosis and death of A549 cells and suppress S180 tumor growth in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21926506
- Volume :
- 87
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- ChemPlusChem
- Publication Type :
- Academic Journal
- Accession number :
- 159863853
- Full Text :
- https://doi.org/10.1002/cplu.202200277