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Asymmetric Michael Reaction of Malononitrile and α,β-Unsaturated Aldehydes Catalyzed by Diarylprolinol Silyl Ether.
- Source :
-
Synlett . Nov2022, Vol. 33 Issue 18, p1831-1836. 6p. - Publication Year :
- 2022
-
Abstract
- An asymmetric Michael reaction of malononitrile and α,β-unsaturated aldehydes catalyzed by a diarylprolinol silyl ether was developed. Michael products were obtained in good yields and with excellent enantioselectivities without the formation of overreaction products. As a malononitrile moiety can be transformed into an alkoxy or amino carbonyl moiety by oxidative transformation, α-chiral esters or amides with all-carbon quaternary centers can be synthesized with excellent enantioselectivities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICHAEL reaction
*SILYL ethers
*MALONONITRILE
*ALDEHYDES
*AMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 33
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 159859850
- Full Text :
- https://doi.org/10.1055/a-1846-5007