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Effectiveness of maternal pertussis vaccination in Singapore: A test-negative case-control study.

Authors :
Chong, Chia-Yin
Tan, Natalie Woon-Hui
Yung, Chee-Fu
Li, Jiahui
Kam, Kai-Qian
Nadua, Karen
Maiwald, Matthias
Sultana, Rehena
Thoon, Koh Cheng
Source :
Vaccine. Nov2022, Vol. 40 Issue 46, p6570-6574. 5p.
Publication Year :
2022

Abstract

Pertussis vaccination (Tdap -Tetanus-diphtheria-acellular pertussis) for pregnant women has been recommended since November 2017 in Singapore. In this prospective test-negative case-control study from 2018 to 2019, we aimed to evaluate vaccine effectiveness (VE) against pertussis infection and pertussis-related intensive care unit (ICU) admission according to Tdap (Tetanus-diphtheria-acellular pertussis) during pregnancy and/or infant pertussis vaccination. A total of 58 children (26 cases, 32 controls) were recruited with 4 ICU admissions. The median age was 3 months (interquartile range [IQR] 1.50–4.56 months). Overall, 25.9 % of mothers had received antenatal Tdap vaccination and 43.1 % of infants received pertussis vaccination, majority only 1 dose. Tdap in pregnancy alone without infant vaccine or with 0–1 infant dose had a VE of 97.62 % (95 % confidence interval [CI] 53.25–99.88 %), 98.17 % (95 %CI 66.61–99.9 %) respectively, against pertussis infection and 71.9 % (95 %CI 0.0–98.64), 75.86 % (95 % CI 0.0–98.78) respectively, against ICU admissions. Conclusion: Maternal Tdap vaccination was highly protective against infant pertussis and should be routinely recommended for all pregnant women. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0264410X
Volume :
40
Issue :
46
Database :
Academic Search Index
Journal :
Vaccine
Publication Type :
Academic Journal
Accession number :
159819575
Full Text :
https://doi.org/10.1016/j.vaccine.2022.09.087