内镜治疗肝细胞癌合并门静脉癌栓患者食管胃静脉曲张 出血后再出血的危险因素分析.

Objective To analyze the rebleeding rate in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) after endoscopic treatment of esophagogastric variceal bleeding and then assessed the risk factors of the rebleeding in the patients. Methods This study retrospectively recruited 169 hepatitis B - associated HCC patients complicated with PVTT and esophagogastric variceal bleeding treated by endoscopy in Department of Gastroenterology, Beijing Di tan Hospital from September 2008 to December 2016. Among them, 47 patients had PVTTlI, 67 patients had PVTTIII, and 55 patients had PVTTIV. Their clinicopathological and follow - up data were retrieved from the medical records and statistically analyzed. Continuous data were compared among groups using ANOVA or Kruskal - Wallis H test. Categorial data were compared among groups using Chi - square test or corrected Fisher test. The Kaplan - Meier curves and Log - rank test were performed to analyze the rebleeding rate and cumulative survival rates after treatment. The univariate multivariate Cox regression analyses were used to identify the risk factors affecting the rebleeding of patients. Results Compared with PVTT II and III, PVTTIV patients had a higher serum level of the direct bilirubin (Z = 6. 153, P = 0. 046). The endoscopy treatment successfully blocked esophagogastric variceal bleeding in all patients. There was no significant difference in the rebleeding rates within six months and a year after the treatment (all P > 0. 05 ). It was also no statistically significant difference in cumulative survival rates in six months and 1 -, 2 -, and 3 - year after the treatment in PVTT lI, III, and N patients (all P > 0 . 05). Cox multivariate regression analysis showed that hepatic encephalopathy (HR = 3. 643, 95 % CI: 2. 099 - 6. 325, P < 0. 001), γ - glutamyltransferase (HR = 1. 002, 95 % CI: 1. 000 - 1. 005, P = 0 029), AFP (HR= 1. 000, 95% CI: 1. 000 -1. 000, P = 0. 002) and numbers of tumor lesions (HR= 1. 647, 95% CI: 1. 011 -2. 684, P = 0. 045) were all independent risk factors for 1 - year rebleeding in these PVTT patients with esophagogastric variceal bleeding after endoscopic treatment. Conclusion Endoscopic hemostasis is a feasible treatment option for HCC patients with PVTT and esophagogastric variceal bleeding. However, there was no significant difference in the rebleeding and cumulative survival rates in these patients. Furthermore, hepatic encephalopathy, γ - glutamyltransferase, AFP and numbers of tumor lesions were all independent risk factors for 1 - year rebleeding in these patients. [ABSTRACT FROM AUTHOR]