间充质干细胞修复跟腱损伤的可行性与优势.

BACKGROUND: The Achilles tendon is a common site of injury in sports, especially in excessive or improper sports, which is more likely to be affected and difficult to recover after injury. To find a safe, effective, and rapid repair method is always the direction of clinical treatment of Achilles tendon injury, but the effect is not ideal. In recent years, due to the strong repair potential, mesenchymal stem cells have been tried to be used in the treatment of a variety of diseases, and some studies have applied mesenchymal stem cells to repair Achilles tendon injury, with good results. OBJECTIVE: To review the application of mesenchymal stem cells derived from bone marrow, adipose tissue, and tendon in the treatment of Achilles tendon injury, and explore the feasibility and advantages of mesenchymal stem cells in the treatment of Achilles tendon injury, providing a new idea for the treatment of Achilles tendon injury. METHODS: The articles included in CNKI database, Wanfang database, Baidu Academic Database, Web of Science database, PubMed database and Google Academic Database were searched by computer. The Chinese and English search terms were “Achilles tendon, Achilles tendon injury, Achilles tendon rupture, stem cells, mesenchymal stem cells, MSCs, biological materials, tissue engineering”. The screened articles were sorted out and summarized, and those that did not meet the inclusion criteria were excluded. Finally, 101 articles were selected for review. RESULTS AND CONCLUSION: The application of mesenchymal stem cells from different tissues independently or in combination with biomaterials is beneficial for tendon injury repair, but the specific mechanisms involved are not clear, which may include the differentiation of mesenchymal stem cells into tendon cells, regulation of growth factor release and tendon related gene expression. Finding the most suitable seed cells and biomaterials for the treatment of Achilles tendon injury is the key to tissue engineering repair of Achilles tendon. [ABSTRACT FROM AUTHOR]